Immuno-targeting of pancreatic cancer stem cells
نویسندگان
چکیده
منابع مشابه
Immuno-targeting of pancreatic cancer stem cells
Pancreatic cancer is a highly aggressive and deadly disease harboring a distinct population of cancer stem cells (CSC) that is not affected by conventional therapies. A new therapeutic approach using the EpCAM/CD3-bispecific antibody MT110 is capable of activating and redirecting cytotoxic T cells to eliminate primary human pancreatic cancer stem cells, which resulted in long-term survival of p...
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Carcinomas of an epithelial-origin account for the majority of all malignant cancers worldwide. As the most common pancreatic cancer, Pancreatic Ductal Adeno Carcinoma (PDAC) is a carcinoma with an extremely high lethality [1-3]. Compared to other cancers originating in the digestive system, the therapeutic outcome of PDAC treatment is the least promising, largely resulting from a lack of sympt...
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Cancer stem cells (CSC) have been identified in an ever-increasing number of human malignancies on the basis of their ability to recapitulate tumors in the ectopic setting and maintain long-term tumorigenic potential. In addition, in pancreatic adenocarcinoma, CSCs may display additional properties, such as relative drug resistance and enhanced invasive and migratory potential that implicate a ...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2012
ISSN: 2162-402X
DOI: 10.4161/onci.19368